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Adipose Tissue And Adipokines In Health And Disease Pdf File

adipose tissue and adipokines in health and disease pdf file

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Published: 26.04.2021

Systemic sclerosis is a multiorgan autoimmune disease characterized by vasculopathy and tissue fibrosis of unknown etiology.

Oxytocin reduces adipose tissue inflammation in obese mice

Metrics details. Obesity and adipose tissue expansion is characterized by a chronic state of systemic inflammation that contributes to disease. The neuropeptide, oxytocin, working through its receptor has been shown to attenuate inflammation in sepsis, wound healing, and cardiovascular disease. The effect of obesity on oxytocin receptor protein and mRNA expression in adipose tissue was evaluated by Western blotting and real-time polymerase chain reaction. At study endpoint adipose tissue inflammation was assessed by measurement of cytokine and adipokine mRNA tissue levels, adipocyte size and macrophage infiltration via histopathology, and plasma levels of adiponectin and serum amyloid A as markers of systemic inflammation.

Role of adipokines in cardiovascular disease

Adipose tissue plays essential roles in maintaining lipid and glucose homeostasis. To date several types of adipose tissue have been identified, namely white, brown, and beige, that reside in various specific anatomical locations throughout the body. The cellular composition, secretome, and location of these adipose depots define their function in health and metabolic disease. In obesity, adipose tissue becomes dysfunctional, promoting a pro-inflammatory, hyperlipidemic and insulin resistant environment that contributes to type 2 diabetes mellitus T2DM. Concurrently, similar features that result from adipose tissue dysfunction also promote cardiovascular disease CVD by mechanisms that can be augmented by T2DM.

adipose tissue and adipokines in health and disease pdf file

The role of adipokines in systemic sclerosis: a missing link?

I. Introduction

Maria E. Trujillo, Philipp E. The endocrine functions of the adipose organ are widely studied at this stage. The adipose organ, and in particular adipocytes, communicate with almost all other organs. Although fat pads have the potential to have a significant systemic impact, adipocytes may also affect neighboring tissues through paracrine interactions.

The journal's aim is to publish articles focused on basic, clinic care and translational research that seeks to prevent rather than treat the complications of endstage liver disease. The Impact Factor measures the average number of citations received in a particular year by papers published in the journal during the two receding years. CiteScore measures average citations received per document published. Read more. SRJ is a prestige metric based on the idea that not all citations are the same. SJR uses a similar algorithm as the Google page rank; it provides a quantitative and qualitative measure of the journal's impact. SNIP measures contextual citation impact by wighting citations based on the total number of citations in a subject field.

Cardiovascular disease CVD remains the biggest cause of death worldwide. As the global population becomes increasingly sedentary, CVD and related diseases such as diabetes and obesity will increase. Mortality is not the only concern; the associated morbidity is placing an ever greater strain on healthcare providers and economies around the world, let alone the societal consequences of an unhealthy population. Risk factors according to the World Heart Federation include hypertension, smoking, type 2 diabetes mellitus, being overweight, hyperlipidaemia, lifestyle poor nutrition and lack of exercise , family history and having suffered a previous cardiovascular event. The underlying cardiovascular pathology varies from defective contractility to inflammation and damage to blood vessels.

 Сядь.  - На этот раз это прозвучало как приказ.

Обменные операции явно не относились к числу сильных сторон Двухцветного: сто песет составляли всего восемьдесят семь центов. - Договорились, - сказал Беккер и поставил бутылку на стол. Панк наконец позволил себе улыбнуться.

 Ты должен это сделать! - потребовала она и, отвернувшись, начала что-то печатать на клавиатуре Большого Брата.  - Мне нужен список очередности работы на ТРАНСТЕКСТЕ. Если Стратмор обошел фильтры вручную, данный факт будет отражен в распечатке.

 Подними. Беккер заморгал от неожиданности. Дело принимало дурной оборот. - Ты, часом, не шутишь? - Он был едва ли не на полметра выше этого панка и тяжелее килограммов на двадцать.

В морг он не пошел, поскольку в этот момент напал на след еще какого-то парня в пиджаке и галстуке, вроде бы штатского. - Штатского? - переспросил Фонтейн. Скорее всего это игры Стратмора: он мудро решил не впутывать в это дело агентство.

 Спасибо.  - Он улыбнулся и сразу перешел к делу.  - Мы вместе спустимся.  - Он поднял беретту.  - Ты найдешь терминал Хейла, а я тебя прикрою.

Беккер искал какой-нибудь перекресток, любой выход, но с обеих сторон были только запертые двери. Теперь он уже бежал по узкому проходу. Шаги все приближались. Беккер оказался на прямом отрезке, когда вдруг улочка начала подниматься вверх, становясь все круче и круче. Он почувствовал боль в ногах и сбавил скорость.

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